Several studies have highlighted that elevated total homocysteine (tHcy) concentrations are linked to an increased risk for coronary, cerebral and peripheral vascular disease. Homocysteine is a sulfur containing amino acid that can be metabolized (re-methylated to methionine) using three different pathways, Vitamin B12-dependant methionine synthase, Betaine-homocysteine methyltranserase or trans-sulfuration. The first pathway uses methyltetrahydrofolate, an...
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5,10-methyltetrahydrofolate reductase (MTHFR)
