Autism spectrum disorders are neurodevelopmental disorders characterised by varying degrees of dysfunctional communication and social interactions, repetitive behaviours as well as learning and sensory deficits. In the last 20 years there has been an impressive rise in autism spectrum disorder with the current prevalence estimated at approximately 1 in 100 children (Theoharides, Angelidou, Alysandratos, Zhang, Asadi, Francis, Toniato & Kaligermitros, 2011). In a recent study, researchers from Tufts University School of Medicine, examined the relationship between genetics, environmental triggers and immune system compromise in children diagnosed with autism spectrum disorder (ASD) (Theoharides, Angelidou, Alysandratos, Zhang, Asadi, Francis, Toniato & Kaligermitros, 2011). In this study, it was suggested that a majority of children with ASD experience allergic symptoms including atopic dermatitis, asthma and rhinitis. Moreover, that using supplements containing therapeutic doses of quercitin and luteolin can reduce acute autistic stress like behaviour and reduce inflammation to the gut brain barrier (leaky gut syndrome), thus reducing acute episodes of allergic symptoms.
Theoharides, T.C., Angelidou, A., Alysandratos, K.D., Zhang, B., Asadi, S., Francis, K., Toniato, E. & Kaligermitros, D. 2011. Mast cell activation and autism. Biochimetica Biophysica Acta, 1-8, In Press.